blood type b and covid vaccine side effects blood type b and covid vaccine side effects

J Med Internet Res (2021) 23:e26089. Factors that influence the concentration of neutralizing antibodies and cellular responses were analyzed using a multivariate linear regression model, which could be set on one of the classified variances as a reference to calculate the B value (18). They also found non-white race, defined as African American, American Indian/Alaskan Native, Native Hawaiian, or Pacific Islander was associated with viral positivity (13.9% vs 6.9%, respectively) and hospitalization (23.9% vs 11.3%) versus white race. Patients' mean age was 42, 77% were women, and most were white. Figure2 Quantitation of antibodies on days 1240 following administration of the Chinese inactivated vaccine. Introduction: In China, the long-term immunogenicity and adverse effects of inactivated vaccines produced by different or the same manufacturer remain unclear. "There are two possibilities: You're Type O so you might not contract the virus because it has no landing stripthere's nothing to attach to," Dr. Udden explains. Case Rep Infect Dis. Many people have reported side effects, such as headache, fatigue, and soreness at the injection site, that are generally mild to moderate and go away within a few days. Unexplained deaths. and transmitted securely. All Rights Reserved. This is why some vaccines require a brief observation period after your shot. Some people with COVID-19 develop abnormal blood clots, including in the smallest blood vessels. The discovery of Type Os protective effect is crucial to building an understanding of how the virus works. As the study is ongoing, further follow-up data on the third dose of a vaccine booster will be reported in the future. BM and JZ collected data and YL reviewed the manuscript. 2022 Galvanized Media. COVID-19; SARS-CoV-2; adverse reaction; neuropathy; side effect; vaccination. According to Pfizer, about 3.8% of their clinical trial participants experienced fatigue as a side effect and 2% got a headache. Both primary and safety analyses included all participants who received two doses of the inactivated vaccine and had suffered local and systemic adverse events for 30 consecutive days after vaccination. Molly Walker, Associate Editor, MedPage Today Hum Vaccin Immunother. Common side effects include fatigue and headache. Exacerbating GuillainBarr syndrome eight days after vectorbased COVID19 vaccination. Hum Vaccin Immunother (2022) 18:2078634. doi:10.1080/21645515.2022.2078634, 9. SARSCoV2 vaccines are not free of neurological side effects. The severity of the COVID-19 disease Recent data suggests that people with blood type A have a significantly higher risk of acquiring COVID-19 than non-A blood types. U.S. federal health agencies have recommended pausing the use of Johnson & Johnson's COVID-19 vaccine after six recipients developed a rare disorder involving blood clots, in a fresh setback to . From days 31 to 240, there was a slight decrease in the GMC of neutralizing antibodies in both groups. An independent data-monitoring committee, comprising independent scientists not involved in this study, has been reviewing the data regularly for safety and scientific integrity. These fun facts about everything from the cosmos to the inner workings of your body will blow your mind. Type O blood, the most common in the U.S., provides some protection against COVID. Glob Health Res Policy (2022) 7:21. doi:10.1186/s41256-022-00255-1, 12. 2021;76:e3286. The pituitary gland in SARS-CoV-2 infections, vaccinations, and post-COVID syndrome. Based on our research, we rate FALSE the claim that 1 million "COVID-vaccine injuries" are reported in a CDC database. Bruising for no. To control the COVID-19 epidemic and build an active immunization barrier among populations, the Chinese Government provided free COVID-19 vaccination to all citizens as of December 2020 (3). The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. By February 21, 2021, more than 46 million persons received at least 1 dose of an mRNA-based COVID-19 vaccine. Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses. The blood group types did not affect the clinical outcomes. According to a CDC study which analyzed the first month of vaccinations, more than 79% of side effects were reported by women, even though women only accounted for 60% of vaccinations given.. In China, the latter three have been approved and are produced by eight manufacturers. Microbiol Spectr (2022) 10:e0118121. The median age at vaccination was 35 years (interquartile range [IQR]: 2850) for those administered a vaccine of the same manufacturer (control) and 33 years (IQR: 2150) for those administered vaccines from different manufacturers (intervention) (Table1). Lower antibody concentrations were correlated with older age, longer duration after vaccination, non-health care workers, mixed-manufacturer vaccinations, and intervals of less than 40 days between two doses of vaccination, whereas lower IFN- levels and B-lymphocyte counts were associated with older age, blood type A, and non-health care workers. We dont know why people with Type O might possibly be more protectedbut there are a lot of theories. In fact, the findings suggest that people with blood type A face a 50 percent greater risk of needing oxygen support or a ventilator should they become infected with the novel coronavirus. Table2 Factors associated with the neutralization antibody concentration after the administration of the Chinese inactivated COVID-19 vaccine. The Centers for Disease Control and Prevention on Friday published new data listing the most common side effects Americans reported after receiving shots of Pfizer 's or Moderna 's Covid-19 vaccines. The log-transformed level of interferon-gamma, CD4+ T-cell count, B-lymphocyte count, and IL-6 level were used as independent variables. Anderson disclosed no relevant relationships with industry. These quick trivia tidbits will help you kill your boredom and impress your friends. Congestion/runny nose. Data were calculated based on a linear mixed-effects model adjusted for vaccine manufacturer, sex, age, blood type, occupation, and body mass index (BMI). Saur D, ORyan M, Torres JP, Zuniga M, Santelices E, Basso LJ. Participants with blood type A and workers had lower levels of IFN- than those with blood type B and medical staff, respectively (B = 0.16, 95% CI 0.040.28, p = 0.01 and B = 0.27, 95% CI 0.46 to 0.07, p = 0.008, respectively; Table3; Figures3B, C). The most frequent of them are headache, GBS, VST, and transverse myelitis. However, some studies have people wondering if blood type affects coronavirus risk. It is suggested that pain in the application area is the most frequent side effect among workers in a Mexican hospital who received the Pfizer BioNTech vaccine against COVID-19. Blood type, the researchers found, stood out as a potential key difference between the two groups. N Engl J Med (2020) 383:201829. The virus can lead to pneumonia, respiratory failure, heart problems, liver problems, septic shock, and death. Opens in a new tab or window, Visit us on Twitter. To address this issue, in 1991, a group of scientists in Minnesotaat the Department of Veterans Affairs and the . Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. In November 2021 in The New England Journal of Medicine, he proposed that an autoimmune mechanism triggered by the SARS-CoV-2 spike protein might explain both Long Covid symptoms and some rare vaccine side effects, and he called for more basic research to probe possible connections. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Whether the immunogenic response observed in this study will translate to better efficacy and effectivenessa fact that should be considered in strategic decisions about vaccination programsis unknown. Front Public Health. why people on blood thinners shouldn't get the vaccine. ABO blood typing was performed using a test-tube method according to the manufacturers protocol (Chengdu Xiehe Ltd., Co., Chengdu, China). Similarly, previous studies reported that patients with blood group A had an increased risk of infection with SARS-CoV-2, whereas those with blood group O were associated with a decreased risk (21, 24). Just because youre Type O doesnt mean youre in the clear. There was no association with blood type and either susceptibility to COVID-19 infection or disease severity in a large cohort study, researchers said. Nous, Yahoo, faisons partie de la famille de marques Yahoo. 2021;8(2021):3619131. doi:10.1155/2021/3619131 It usually occurs soon after vaccination, and can be treated with epinephrine (as in an EpiPen). (D) Kinetics of B-lymphocyte count according to age. Now, a "Covid arm" is different from a skin reaction that . They noted conflicting research about blood types and COVID, with studies around the world finding links between the two -- particularly, increased susceptibility in people with type A and/or decreased risk with type O -- while others found no links. -. She is a 2020 J2 Achievement Award winner for her COVID-19 coverage. The most basic idea is that blood type might influence a persons ability to fight the virus, says David Aronoff, M.D., director of the division of infectious diseases at Vanderbilt University Medical Center in Nashville. As of Dec. 24, there were more than 700,000 reports of adverse events . The blood type-infection connection is not unique to the coronavirus. There was no association with blood type and either susceptibility to COVID-19 infection or disease severity in a large cohort study, researchers said. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Participants in the mixed-manufacturer vaccination group, those with an interval of >40 days between doses of vaccination, and workers produced lower levels of IL-6 than those in the same-manufacturer vaccination group, those with an interval of <40 days between doses of vaccination, and medical staff (B = 0.01, 95% CI 0.014 to 0.003, p = 0.003, B = 0.44, 95% CI 0.8 to 0.1, p = 0.019, and B = 1.5, 95% CI 2.1 to 0.9, p < 0.001, respectively; Table6; Figures3FH). . Adverse reactions were mild or moderate and self-limited, with no serious events reported. Editorial: Rebound COVID-19 and cessation of antiviral treatment for SARS-CoV-2 with paxlovid and molnupiravir. P=0.11), hospitalization (OR 0.89, 95% CI 0. . The following outcomes were selected and defined by the authors based on information from regulatory authorities, previous studies, large-scale adverse events initiatives: febrile seizure, aseptic. Amyloid -related angiitis of the central nervous system occurring after COVID-19 vaccination: A case report. Anderson's group examined data from Intermountain Healthcare, an integrated system of 24 hospitals and 215 clinics in Utah, Idaho, and Nevada. Immune cellular responses at 1240 days after the second dose of vaccine also supported the same manufacturers approach. Nat Commun (2020) 11:5761. doi:10.1038/s41467-020-19623-x, 20. COVID-19 vaccine hesitancy in Africa: A scoping review. Safety of COVID-19 Vaccines Some people have no side effects. Costa Clemens SA, Weckx L, Clemens R, Almeida Mendes AV, Ramos Souza A, Silveira MBV, et al. In 2020, scientists started talking about a link between blood type and Covid. (19, 20), we divided participants into three BMI groups: <18.5, 18.523.9, and >23.9 kg/cm2. Tenforde MW, Self WH, Adams K, Gaglani M, Ginde AA, McNeal T, et al. Figure3 Quantitation of cell immune responses on days 1240 following administration of the Chinese inactivated vaccine. To date, coronavirus disease 2019 (COVID-19), a newly emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 600 million people worldwide and killed over 6 million people (1, 2). In both groups, most of the adverse events were mild (n = 25, 81.1%) or moderate (n = 6, 18.9%) and self-limited. Science-based COVID-19 vaccine development. Published by John Wiley & Sons Ltd. Lancet Respir Med (2022) 10:73948. Wheatley AK, Juno JA, Wang JJ, Selva KJ, Reynaldi A, Tan HX, et al. doi: 10.1016/S2213-2600(21)00220-4, 19. xhr.send(payload); "The long-term side effects of COVID infection are a major concern," Goepfert said. YY and JX designed the study, analyzed the data, and wrote the manuscript. The development of a vaccine that can overcome disadvantages including the stability of the materials used, limited immune response, and side effects, such as blood clotting, and provide a durable immune response will offer better protection from the deadly COVID-19 virus, the study said. All rights reserved. Safety definitions and a list of solicited adverse events were defined as previously described (16, 17). You will see significant upgrades in-store and online this year. Library job allowed him to plan the escape. A previous study in the journal Blood Advances from 2020 also affirmed this research, adding that people with Type O blood seem to be more protected from Covid. It's normal to experience side effects after the vaccine. (A) Positive rates of neutralizing antibodies. Lancet Infect Dis (2022) 22:47382. 8600 Rockville Pike It's becoming more common in people under 55. Third, because of limited resources, we could not perform pseudo-virus neutralization tests of neutralizing antibodies against COVID-19 (27). Nausea. Even DNA testing company 23andMe tapped their customers and found that among 750,000 people who were diagnosed and hospitalized for Covid (this was prior to vaccines), those with type O were more protected. In contrast, we observed a decrease in the B-lymphocyte count and IL-6 level on days 1 to 240 in participants stimulated with the SARS-CoV-2 S antigen (B = 0.004, 95% CI 0.005 to 0.003; p = 0.008 and B = 0.004, 95% CI 0.006 to 0.002, p = 0.001, respectively; Tables5, 6; Figures3A, G). Those who are O-negative may be the least likely to get COVID. Experts say more . 1 The symptoms commonly reported were similar to those already associated with COVID-19 vaccines like fatigue, headache, and muscle pain. It varies from person to person, but how dramatic the initial response is does not necessarily relate to the long-term response. There's no known connection between blood types and side effects from COVID-19 vaccines. But VWF also . The population required to be vaccinated included children aged 311 years, adolescents aged 1217 years, and adults. Kinetics and persistence of the cellular and humoral immune responses to BNT162b2 mRNA vaccine in SARS-CoV-2-naive and -experienced subjects: Impact of booster dose and breakthrough infections. Treatment of these side effects is not at variance from similar conditions due to other causes. The levels of cellular immune molecules, such as IFN- and CD4+ T-lymphocytes, reflect the levels of effector molecules involved in the humoral immune response, such as memory B cells and neutralizing antibodies (26). Socio-economic status is a big vulnerability, and age and health are next in line for susceptibility. The multiple linear regression analysis revealed that participants aged >50 years had lower reactive IFN- levels and B-lymphocyte counts than those aged 1830 years (Tables36, Figures3AG; Tables S8S15) (B = 0.15, p = 0.03; B = 0.04, p = 0.036, respectively) (Tables3, 5; Figures3A, D). Epub 2021 Aug 28. Further inquiries can be directed to the corresponding author. Lustig Y, Sapir E, Regev-Yochay G, Cohen C, Fluss R, Olmer L, et al. Acceptance of COVID-19 booster vaccination based on the protection motivation theory: A cross-sectional study in China. Domingo JL. If youre older or have an underlying disease like cancer, diabetes, or heart disease, youre more likely to develop a severe case of coronavirus, Dr. Udden adds. In this study, the older population produced lower levels of neutralizing antibodies, IFN-, B-lymphocytes, and IL-6, similar to that in previous studies (3, 25). Table1 Baseline characteristics of the study participants (N = 595). Dr. Susan R. Bailey, an allergist, immunologist and president of the American Medical Association, said side effects develop because your immune system is reacting to the vaccine. All analyses, including linear regression, linear mixed models, and adverse effect analysis, were conducted using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) and plotted using Prism 8.0. It's more the everyday things: According to Harvard Medical School physician Abraar Karan, the primary side effects of the COVID-19 vaccine are those pesky, flu-like, symptoms you're used. Epub 2021 Oct 31. We know the Covid virus damages the lining of your blood vessels. Four types of COVID-19 vaccine have been approved for use worldwide: mRNA, inactivated virus, adenovirus, and recombinant protein vaccines (11). The difference may be the type of antibodies we produce depending on blood type. Neutralizing antibody levels were associated with a 33.89% decrease in anti-SARS-CoV-2 spike protein IgG standardized ELISA titers 180 days after the second vaccination (21), similar to our results, that is, a 32.3% decrease in neutralizing antibody levels in the following 180 days. "It's pretty clear that Type O is protective to some degree. Methods: This prospective, multicenter, observational, longitudinal study involved 595 participants with a negative SARS-CoV-2 polymerase chain reaction result who were serologically tested and followed for 8 months after vaccination. The inactivated vaccine was administered as a single intramuscular injection for each of the two approved doses. This weird trivia you didn't know about the world will blow you away. Since both of those types are fairly rare, the Red Cross works hard to . If you are hesitant because of the possibility of COVID vaccine side effects, the good news is, the risk of a severe reaction is low andDr. The study complied with the principles of the Declaration of Helsinki and Good Clinical Practice, and was approved by the Ethics Committee of Henan Provincial Peoples Hospital (approval number 20210051, date of approval May 24, 2021). Up to 10 percent of people who have COVID experience side effects" such as difficulty thinking, pain, tiredness, loss of taste and depression. Co-authors disclosed support from Dell Loy Hansen Heart Foundation Heart Institute, Intermountain Research and Medical Foundation, AstraZeneca, PCORnet, GlaxoSmithKline, CareCentra, and LabMe.ai, as well as licensing of intellectual property from Alluceo and CareCentra. Shes most passionate about hiking, traveling, mindfulness, cooking, and really, really good coffee. Yin F, Wu Z, Xia X, Ji M, Wang Y, Hu Z. Vaccine induced immune thrombotic thrombocytopenia causing a severe form of cerebral venous thrombosis with high fatality rate: a case series. Lancet Infect Dis (2022) 22:5663. However, in this study, the GMC in participants in the mixed-manufacturer group was lower than that in participants in the same-manufacturer group, which is perhaps due to the fact that vaccines from different manufacturers were still of the same type (both inactivated vaccines, but a protein or attenuated live vaccine). BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: A prospective, single-centre, longitudinal cohort study in health-care workers. Environ Res (2022) 215:114131. doi:10.1016/j.envres.2022.114131, 3. 2021;30(12):721146. doi:10.3389/fneur.2021.721146 Natl Sci Rev (2021) 8:nwab193. A new study has good news for more than a third of Americans. Table6 Factors associated with IL-6 level after the administration of the Chinese COVID-19 inactivated vaccine. BMI, body mass index; LSMD, least-square mean difference. Eur J Med Res. Rachael Schultz is a freelance writer who focuses primarily on why our bodies and brains work the way they do, and how we can optimize both (without losing our sanity). A total of 1,350 serum samples were collected from 595 participants (Figure1), of whom 457 (76.8%) were medical staff and 138 (23.2%) were workers of the Henan Electric Power Exploration Company in central China. Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19. Wu F, Yuan Y, Deng Z, Yin D, Shen Q, Zeng J, et al. -, Wiedmann M, Skattr T, StrayPedersen A, et al. doi:10.1016/S0140-6736(22)00770-X, 26. Where are we now, in 2022, on blood type and Covid? Parameters of cell immune responses were evaluated by quantifying the levels of interferon (IFN)-, interleukin (IL)-6, and CD4, and counts of B-lymphocyte subsets in the plasma after overnight stimulation of whole blood with 2 g/mL SARS-CoV-2 spike peptides (Wuhan Huamei Biotechnology Ltd., Co., Wuhan, China) or dimethyl sulfoxide in whole-blood culture as a control, requiring only 2 mL blood (14). Lorsque vous utilisez nos sites et applications, nous utilisons des, authentifier les utilisateurs, appliquer des mesures de scurit, empcher les spams et les abus; et. if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { National Library of Medicine There have been multiple studies on blood types and COVID-19 risk. They looked at both how likely a patient was to contract COVID-19, and how likely they were to become seriously ill (or even die) from it if they did. Blood type may influence other infections, as well. Use or keep moving your arm. The concentration kinetics of IgG neutralizing antibodies were evaluated against the RBD for all study participants at least once during the 8-month timeframe and at least four times for 119 participants (20%). In fact, one might say that people on . This can progress to affect the rest of the body and cause. In the case of the two mRNA COVID-19 vaccines, well over 90% of . Either way, that would color how likely you are to not only get the virus but also how strong your symptoms are, he explains. But the seemingly-banal detail might be a factor in who is most susceptible to Covid 19. The full eligibility criteria were provided in the volunteer recruitment notification distributed through social networks, including WeChat groups. Unable to load your collection due to an error, Unable to load your delegates due to an error. The retailer's cutting-edge new offering is angering some local residents. Side effects can be a powerful deterrent stopping people from getting vaccinated. But the virus is still in your system and you can still pass it to someone else.". But theres another interesting layer to a potential protective element in Type O blood: something called von Willebrand factor, which is a glycoprotein in charge of repairing damage to blood vessels by prompting your blood to clot. In addition, a 2020 analysis in The Lancet found that compared to Covid patients who werent in intensive care, those who were critically ill in the ICU and died had higher VWF antigens in their blood. "Up to 10 percent of people who have COVID experience side effects such as . doi:10.2196/26089, 24. To our knowledge, this study is the first to report that a heterologous Chinese COVID-19 inactivated vaccine administration schedule induced humoral and cellular immune responses in humans and that it was associated with an acceptable and manageable reactogenicity profile 240 days after vaccination. ae0fcc31ae342fd3a1346ebb1f342fcb, "An Rh status seemed protective against SARS-CoV-2 infection," the study authors wrote. The side effects mean your body is working hard to build the antibodies and cells it will need to fight the virus, if or when you are exposed to it. Doctors aren't yet sure if there is a link between the . Comment on "SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fiber neuropathy by J. Finsterer. The blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (57% vs. 38%, P < 0.001; OR: 2.1). Opens in a new tab or window, Visit us on Instagram. Disclaimer. doi:10.1016/S2213-2600(22)00087-X, 8. } Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case series. Neutralizing antibodies, interferon-gamma (IFN-), interleukin (IL)-6, CD4+ T-lymphocyte, and B-lymphocyte counts were evaluated in serum samples after stimulation with 2 g/mL SARS-CoV-2 spike protein for 16h at follow-up intervals of 2 months. Brand of vaccine administered (Moderna or Pfizer-BioNTech) and the change in average blood glucose, peak blood glucose, and percentage of time spent in normal range as well as above average range of blood glucose level following vaccine administration will be assessed.